HOLM, Ida Elisabeth,JOHANSEN, Marianne Gregers,JAKOBSEN, Jannik Ejnar,JØRGENSEN, Arne Lund,NIELSEN, Anders Lade
申请号：
DK20080715608T
公开号：
DK2134846(T3)
申请日:
2008.03.06
申请国别(地区):
丹麦
年份:
2018
代理人:
摘要：
The present invention relates to a modified pig as a model for studying Alzheimer's disease. The modified pig model displays one or more phenotypes associated with Alzheimer's disease. Disclosed is also a modified pig comprising a modified human and/or porcine APP gene, and/or PS1 gene, and/or a transcriptional and/or translational product or part thereof. The invention further relates to methods for producing the modified pig; and methods for evaluating the effect of a therapeutical treatment of Alzheimer's disease; methods for screening the efficacy of a pharmaceutical composition; and a method for treatment of a human being suffering from Alzheimer's disease are disclosed.
