Embodiments are disclosed of a method of controlling timing and/or dosage of a transdermal drug patch. For example a control device operative to move the patch to one or more of a plurality of operational relationships with a skin of a patient including being fully engaged with the skin partially engaged with the skin and disengaged with the skin. The device may include a roller that peels a patch on and off the skin. Optionally a convention patch is used. In some embodiments a patch and/or an adaptor has a mobile zone and an immobile zone. In some embodiments an active surface of the patch fully contacts the skin in an engaged state. For example the patch may be attached to the device on a passive portion thereof.
