Benzamidni derivati za inhibiranje aktivnosti ABL1, ABL2 in BCR-ABL1

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专利权人:

Novartis AG

发明人:

DODD Stephanie Kay,FURET Pascal,GROTZFELD Robert Martin,JONES Darryl Brynley,MANLEY Paul,MARZINZIK Andreas,PELLE Xavier Francois Andre,SALEM Bahaa,SCHOEPFER Joseph,JAHNKE Wolfgang,MARZ

申请号：

SI201330997

公开号：

SI2861579T1

申请日:

2013.05.09

申请国别(地区):

SI

年份:

2018

代理人:

摘要：

The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention； capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

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