Amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres

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专利权人:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人:

Dong, Yizhou,Love, Kevin,Langer, Robert,Anderson, Daniel,Chen, Delai,Chen, Yi,Vegas, Arturo,Alabi, Akinleye,Zhang, Yunlong

申请号：

NZ74750112

公开号：

NZ747501A

申请日:

2012.10.26

申请国别(地区):

NZ

年份:

2020

代理人:

摘要：

Described herein are compounds and compositions that are characterized by the Markush formula (II-a) underneath, where at least one terminal amino group is further functionalized by bearing a group of type (i), (ii), or (iii). Such compounds are obtained by reacting a terminal or internal amino group with epoxides, acrylates, or aldehydes bearing lipophilic groups. The resulting amino acid, peptide, polypeptide-lipids (named “APPLs” in the application) are deemed useful as drug delivery systems including nucleotide delivery to cells.

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