A cartridge for holding surgical fasteners includes a base having a plurality of upstanding walls, adjacent pairs of walls defining spaces for holding surgical fasteners, at least one surgical fastener securing member movably connected to the base and movable relative to the base from an open position wherein fasteners can be loaded into the spaces, and a closed position wherein fasteners in the spaces are covered and held in the spaces, and a locking structure engageable between the base and the surgical fastener securing member for locking the surgical fastener securing member in the closed position.
