An intravenous connection site protective device encloses an intravenous connection site and prevents tampering with and inadvertent separation of intravenous lines. The device includes an elongated sleeve having an interior space. Respective apertures extend through a first end and a second end of the sleeve. Each aperture receives an intravenous line therethrough. The interior space holds an intravenous line port coupled to a free end of one of the intravenous lines. A first section of the sleeve pivotally coupled to a second section providing access to the interior space. A closure secures the first section to the second section in a closed position wherein access to the interior space is inhibited by the sleeve.
