公益財団法人がん研究会;JAPANESE FOUNDATION FOR CANCER RESEARCH
发明人:
ISHIKAWA Yuichi,石川 雄一,ONO Hiroshi,小野 宏,石川 雄一,小野 宏
申请号：
JPJP2013/066947
公开号：
WO2013/191242A1
申请日:
2013.06.20
申请国别(地区):
JP
年份:
2013
代理人:
摘要：
[Problem] In small cell lung cancer (SCLC), there are a type having poor prognosis and a type having good prognosis. It has been demanded to detect small cell lung cancer at an earlier stage and establish a treatment method for small cell lung cancer. The present invention provides: a test method which can detect small cell lung cancer having poor prognosis； a means for treating small cell lung cancer having poor prognosis； and a method for screening for a drug for treating small cell lung cancer having poor prognosis.[Solution] It is found that HOTAIR (for which cDNA comprises the nucleotide sequence represented by SEQ ID NO: 1), which is lincRNA, is highly expressed in small cell lung cancer having poor prognosis. The present invention is a diagnosis method for determining whether or not small cell lung cancer is one having poor prognosis, wherein the prognosis of the small cell lung cancer is determined as being poorer when the amount of HOTAIR, which is lincRNA, expressed in a sample of the small cell lung cancer is higher. Further, siRNA which can inhibit the proliferation of small cell lung cancer in which HOTAIR is highly expressed is discovered.[Problème] Dans le cancer du poumon à petites cellules (SCLC), il existe un type ayant un faible pronostic et un type ayant un bon pronostic. Il a été demandé de détecter le cancer du poumon à petites cellules à un stade précoce et d'établir un procédé de traitement pour le cancer du poumon à petites cellules. La présente invention concerne : un procédé de test qui peut détecter le cancer du poumon à petites cellules ayant un faible pronostic ； un moyen de traitement du cancer du poumon à petites cellules ayant un faible pronostic ； et un procédé de criblage pour un médicament pour traiter le cancer du poumon à petites cellules ayant un faible pronostic.[Solution] Il a été trouvé que HOTAIR (pour lequel l'ADNc comprend la séquence nucléotidique représentée par SEQ ID NO : 1), qui est un grand ARN intergénique non
