process for preparing 5 - [(r) -2- (5,6-diethyl-indan-2-ylamino) -1-hydroxy-ethyl] -8-hydroxy- (1h) -quinolin-2-one salt, intermediates as well as salt thus obtained
"Process for the preparation of 5 - [(r) -2- (5,6-diethyl-indan-2-ylamino) -1-hydroxy-ethyl-8-hydroxy (1h) quinolin-2-one salt, useful as an adrenoceptor agonist. " The present invention relates to a process for the preparation of 5 - [(r) -2- (5,6-diethyl-indan-2-ylamino) -1-hydroxy-ethyl] -8-hydroxy- ( 1h) -quinolin-2-one. the process involves the formation of an oxy (1h) quinolin-2-one acid 5 - [(r) -2- (5,6-diethyl-indan-2-ylamino) -1-hydroxy-ethyl] -acetic acid salt. 8-Substituted and Acidate Salt Coverage to a 5 - [(r) -2- (5,6-diethyl-indan-2-ylamino) -1-hydroxy-ethyl] -8-hydroxy- (1h) -quinolinecarbonate salt 2-one without separation of 5 [(r) -2- (5,6-diethyl-indan-2-ylamino) -1-hydroxy-ethyl] -8-hydroxy- (1h) -quinolin-2-free base one."processo para a preparação de sal de 5-[(r)-2-(5,6-dietil-indan-2-ilamino)-1-hidróxi-etili-8-hidróxi-(1h)quinolin-2-ona, útil como um agonista do adrenoceptor". a presente invenção refere-se a um processo para a preparação de sal de 5-[(r)-2-(5,6-dietil-indan-2-ilamino)-1-hidróxi-etil]-8-hidróxi-(1h)-quinolin-2-ona. o processo envolve a formação de um sal ácido de oxi-(1h)quinolin-2-ona 5-[(r)-2-(5,6-dietil-indan-2-ilamino)-1-hidróxi-etil]-8-substituída e coversão do sal ácido a um sal de 5-[(r)-2-(5,6-dietil-indan-2-ilamino)-1hidróxi-etil]-8-hidróxi-(1h)-quinolin-2-ona sem separação da base livre da 5[(r)-2-(5,6-dietil-indan-2-ilamino)-1 -hidróxi-etil]-8-hidróxi-(1h)-quinolin-2-ona.
