‘Osorno’ is a new blueberry cultivar of primarily Vaccinium corymbosum. The rest of its parentage is from V. darrowii (13.3%), V. angustifolium (3.8%), V. tenellum (<1%), and V. ashei (<1%). It is a highly productive cultivar with exceptional fresh fruit quality. It is likely best adapted to the northern highbush production areas where winters are not severe, such as central Chile and the Pacific Northwest, but it is recommended for further trial in colder production regions such as Michigan. Plants of ‘Osorno’ are vigorous and upright, although the canes can be lax when loaded with fruit. Canes are numerous, moderately branched and the fruit are well exposed. Its berries are large, have small, dry picking scars, light blue color, and excellent firmness and flavor. Its fruit held up extremely well in the unseasonably hot summer of 2012, when temperatures routinely exceeded 30 C.