STEFAN BRACHT,PIRJO KORTESUO,MIKAEL STOLT,MANJA AHOLA,HARRI JUKARAINEN,HEIKKI LYYTIKINEN
申请号：
ARP120104055
公开号：
AR088578A1
申请日:
2012.10.30
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
This relates to the field of Drug Delivery Systems. More particularly, This refers to osmotically Active intravaginal administration systems for the controlled release of Therapeutically active substances in the vaginal Cavity.Claim 1: a system of osmotically Active vaginal Administration, Whose Body comprises: at least one compartment comprising a Composition of one or more Therapeutically active substances, at least one compartment, either the same or different comprising the substance (S) ( Therapeutically Active (S) S)Osmotic comprising a composition capable of interacting with water and / or organic aqueous Fluid to create a concentration gradient against the outside fluid and swell or expand to create Osmotic pressure.And at least one passage that extends from the compartment comprising the composition of one or more Therapeutically active substances to the Outer surface of the body.Claim 3: an osmotically Active vaginal administration system according to claim 1, wherein at least part of the system of Administration is covered by a Membrane comprising a Polymer composition which is permeable to the passage of water or Fluid Aqueous external present in the vaginal Cavity, but is impermeable to the compositions within the system.9: a Vindication of osmotically Active vaginal administration system according to claim 8, wherein the Waterproof Membrane or barrier Layer comprises a material which constitutes a barrier to the diffusion of pharmaceutically active substances S and preferably Selects, among the Group comprising siloxane Polymers, teflonSiloxane Polymers and copolymers of teflon, polyacrylonitrile or olefins.Claim 12: an osmotically Active vaginal administration system according to any of the preceding Claims, wherein the material of the body is a barrier to Diffusion for pharmaceutically active substances and selected, preferenteme NTE, between the group of siloxane Polymers, polyurethane, polyurethane elastomer, polyacrylonitrile,Copolymer of ethylen
