WEBSTER, SCOTT PETER,SECKL, JONATHAN ROBERT,WALKER, BRIAN ROBERT,WARD, PETER,PALLIN, THOMAS DAVID,DYKE, HAZEL JOAN,PERRIOR, TREVOR ROBERT
申请号：
ES09718896
公开号：
ES2545489T3
申请日:
2009.03.13
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
An amido-thiophene compound selected from the compounds of the following formula, and pharmaceutically acceptable salts, hydrates and solvates thereof: ** Formula ** in which: - R2 is independently -R2B； - R3 is independently -H； - R5 is independently -H； and - Z is independently -J1, -J2 or -J3； wherein: - R2B is independently pyrazolyl, and is optionally substituted with one or more substituents independently selected from: -RX1, -F, -Cl, -Br, -OH, -ORX1, -NH2, -NHRX1, -NRX1 2, -NHC (>； = O) RX1 and - NRX1C (>； = O) RX1； wherein each -RX1 is independently saturated aliphatic C1-4 alkyl or phenyl； wherein: - J1 is independently a non-aromatic monocyclic heterocyclyl group having 4 to 8 ring atoms, in which exactly 1 of said atoms in the ring is a cyclic heteroatom, and is N, or exactly 2 of said atoms in the ring they are cyclic heteroatoms, and they are both N, or exactly 2 of said atoms in the ring are cyclic heteroatoms, and they are N and O, or exactly 2 of those atoms in the ring are cyclic heteroatoms, and they are N and S, and wherein said non-aromatic heterocyclyl group is optionally substituted； - J2 is independently a non-aromatic fused bicyclic heterocyclyl group having 7 to 12 ring atoms, in which exactly 1 of said atoms in the ring is a cyclic heteroatom, and is N, or exactly 2 of said atoms in the ring. ring are cyclic heteroatoms, and they are both N, or exactly 2 of said atoms in the ring are cyclic heteroatoms, and are N and O, or exactly 2 of those atoms in the ring are cyclic heteroatoms, and they are N and S, or exactly 3 of said ring atoms are cyclic heteroatoms, one of which is N, and each of the other two is independently N, O or S, and wherein said non-aromatic fused bicyclic heterocyclyl group is optionally substituted； and - J3 is independently a non-aromatic bridged heterocyclyl group having 7 to 11 ring atoms, wherein exactly 1 of said ring atoms is a cyclic heteroatom, and is N, or exactly 2 of said atoms in the ring. ring are cycli
