Pharmaceutical compositions and therapeutic methods employing a combination of a complex compound of manganese and a complex form without manganese of the compound
A pharmaceutical composition for use in reducing the absorption of manganese in the brain of a patient when a disease state in a patient caused by the presence of oxygen-derived free radicals is treated by administration of a manganese complex of a compound of formula I, in an amount effective to treat the condition, the pharmaceutical composition comprising, as the first component, the manganese complex of a compound of formula I, in an amount effective to treat the condition, and as a second component, a compound of formula I or a manganese-free metal complex of a compound of formula I, in an amount effective to reduce the absorption of manganese in the patient's brain compared to administration of the first component in the absence of the second component, wherein the second component is included in an amount of about 1 to 20 μmol / kg of a patient's body weight, and n where the first component and the second component are included in a first component: second component molar ratio in the range of about 1: 1 to 1:10, and where the first component and / or the second component are optionally together with one or more physiologically acceptable carriers and / or excipients, ** (See formula) ** where X represents CH or N, each R1 independently represents hydrogen or -CH2COR5； R5 represents hydroxy, ethylene glycol, glycerol, optionally hydroxylated alkoxy, amino or alkylamido； each R2 independently represents ZYR6 where Z represents a bond, CO or a C1-3 alkylene group or an oxoalkylene group optionally substituted by R7； Y represents a bond, an oxygen atom or NR6； R6 is a hydrogen atom, COOR8, alkyl, alkenyl, cycloalkyl, aryl or aralkyl, group optionally substituted by one or more groups selected from COOR8, CONR82, NR82, OR8,>； = NR8,>； = O, OP (O) ( OR8) R7 and OSO3M； R7 is hydroxy, an optionally hydroxylated or optionally alkoxylated alkyl or aminoalkyl group； R8 is a hydrogen atom or an optionally hydroxylated or optionally alkoxylated alkyl group； M is a hy
