The use of metallic devices and implants, such as intravascular stents, has been an important medical advancement in efforts to decrease morbidity and mortality. However, such the utility of such means is often limited by biological incompatibility and long-term complications, such as persistent inflammation, thrombosis and inappropriate local reactions. Here, we present an invention wherein an efficient method of applying a multilayer biopolymer coating -- such as carrageenan, chitosan, and hyaluronan --- to metallic surfaces is presented. This method should increase biocompatibility and prevent unwanted rejection. This can be applied to implantable biodevices and other metallic devices used for interventional medical purposes.
