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STABLE COMPOSITIONS FOR INCRETIN MIMETIC COMPOUNDS
专利权人:
Delpor; Inc.
发明人:
Gregory A. Watkins
申请号:
US16336086
公开号:
US20190224122A1
申请日:
2017.09.22
申请国别(地区):
US
年份:
2019
代理人:
摘要:
A composition comprising an aqueous suspension comprising an incretin mimetic and an organic acid is described. The organic acid is one that (i) has a water solubility at room temperature of between about 0.01 and 10 g/L, (ii) has a molar mass of less than about 500 grams per mole, and/or (iii) maintains a pH of the suspension in its environment of use of between 3.0-6.0 for a period of at least about 30 days, and stabilizes the incretin mimetic to provide a composition that is suitable for delivering the compound in a biologically active or potent form for a sustained period of time. Devices comprising the compositions and methods of treatment are also described.
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