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Method for inhibiting bone resorption
专利权人:
Amgen Inc.
发明人:
Padhi, Ian Desmond,Jang, Graham Richard
申请号:
AU2008302313
公开号:
AU2008302313C1
申请日:
2008.09.17
申请国别(地区):
AU
年份:
2014
代理人:
摘要:
The invention is directed to a method of inhibiting bone resorption. The methodcomprises administering to a human an amount of sclerostin inhibitor that reducesa bone resorption marker level for at least 2 weeks. The invention also providesa method of monitoring anti-sclerostin therapy comprising measuring one ormore bone resorption marker levels, administering a sclerostin binding agent,then measuring the bone resorption marker levels. Also provided is a method ofincreasing bone mineral density; a method of ameliorating the effects of an osteoclast-relateddisorder; a method of treating a bone-related disorder by maintaining bone density;and a method of treating a bone-related disorder in a human suffering from or atrisk of hypocalcemia or hypercalcemia, a human in which treatment with a parathyroidhormone or analog thereof is contraindicated, or a human in which treatment witha bisphosphonate is contraindicated.
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