Gene Silencing by Single-Stranded Polynucleotides

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专利权人:

发明人:

Gretchen M. Unger

申请号：

US13848249

公开号：

US20130267577A1

申请日:

2013.03.21

申请国别(地区):

US

年份:

2013

代理人:

摘要：

The present invention relates to compositions and methods for concurrently activating antisense and double-stranded RNase (dsRNase) mechanisms for inhibiting expression of a targeted gene, by delivering a single stranded bifunctional chimeric DNA/RNA oligonucleotide optimized for siRNA activity as well as antisense activity, into the nucleus of a target cell.

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