The invention relates to a neuroprotective composition derived from mesenchymal stem cells, especially a neuroprotective composition derived from the primary culture of dental pulp mesenchymal stem cells, its preparation process and its medical uses in the treatment of neurological diseases associated with neuronal damage, including subarachnoid hemorrhage and Parkinson’s disease.本發明涉及一種源自間充質幹細胞的神經保護組合物,特別是一種源自於牙髓間充質幹細胞初代培養物的神經保護組合物。本發明還涉及一種製備所述神經保護組合物的方法,以及所述神經保護組合物在治療與神經元損傷相關的神經系統疾病中的醫藥用途,所述疾病包括蛛網膜下腔出血和帕金森氏症。