A system is described for breast imaging that includes spatially registering sequential mammographic images of the same breast. The system includes a first compression member configured to contact a first side of a breast, a second compression member configured to contact a second side of a breast that is substantially opposite the first side. The system further includes a first image sensor, coupled to the first compression member and configured to detect a position of a first fiducial marker located at the first side of the breast, and a second image sensor, coupled to the second compression member and configured to detect a position of a second fiducial marker located at the second side of the breast.
