KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
发明人:
You-Soo Park,Cheol-Hun Son,Kwangmo Yang
申请号：
US15822843
公开号：
US20180155690A1
申请日:
2017.11.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided is a method for preparing natural killer cell with high efficiency using irradiated peripheral blood mononuclear cells, more particularly to a method for proliferating highly activated NK cells using a combination of irradiated peripheral blood mononuclear cells (PBMCs) and a CD16 antibody and an anti-cancer cell therapeutic composition containing the natural killer cells (NK cells) prepared thereby. Further provided is a method for large-scale proliferation of activated NK cells with high efficiency using a combination of irradiated peripheral blood mononuclear cells (PBMCs) and a CD16 antibody without the use of cancer cells or genetically modified feeder cells having safety issues as feeder cells. The highly purified and highly cytotoxic NK cells proliferated in large quantities can be used as an active ingredient of a cancer immunotherapeutic composition.
