Novel chemical conjugates derived from unsaturated fatty acids and therapeutically active agents, are disclosed. The chemical conjugates are designed and characterized as COX-2 and/or 5-LOX inhibitors and are useful in the treatment of inflammatory diseases and disorders such as Alzheimers disease, Parkinsons disease, asthma, osteoarthritis, rheumatoid arthritis, pain, primary dysmenorrhea, Crohns disease and ulcerative colitis. Novel chemical conjugates derived from unsaturated fatty acids and therapeutically active agents, are disclosed. The chemical conjugates are designed and characterized as COX-2 and/or 5-LOX inhibitors and are useful in the treatment of inflammatory diseases and disorders such as Alzheimers disease, Parkinsons disease, asthma, osteoarthritis, rheumatoid arthritis, pain, primary dysmenorrhea, Crohns disease and ulcerative colitis. The present invention provides a self-operated device for treating a skin of a patient, comprising: a. a substrate having a first side and a second side b. a plurality of RF electrodes arranged in said substrate, said RF electrodes are configured to emit RF radiation from said first side to the surface of said skin c. at least one RF generator configured to generate pulses of current to said RF electrodes and, d. a control unit connected to said at least one RF generator, said control unit is adapted to control the operation of said RF electrodes wherein said control unit is adapted to control the operation of said RF electrodes according to a predetermined treatment protocol, such that the same activates or deactivates at least one of said RF electrodes at any predetermined time interval according to a predetermined pattern so as to achieve a particular therapeutic result.Se describen conjugados químicos novedosos derivados de ácidos grasos insaturados y agentes terapéuticamente activos. Los conjugados químicos están diseñados y caracterizados como inhibidores de COX-2 y/o 5-LOX y son útiles en el tratamiento de enf
