The United States of America; as represented by the Secretary of Agriculture
发明人:
Kay S. Faaberg,Allyn Spear,Matthew A. Kappes,Kelly M. Lager
申请号：
US15989454
公开号：
US20180344837A1
申请日:
2018.05.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Multiple DIVA vaccines effective against porcine reproductive and respiratory syndrome virus (PRRSV) are disclosed. The DIVA vaccines may be negative DIVAs or positive DIVAs. The DIVA vaccines may be produced by modifying the nsp2 region of a modified live virus vaccine. The modification may be one or more deletions only (negative DIVAs) or a deletion with an insertion (positive DIVAs). The insertion may be of an epitope tag, such as a V5, S-Tag, or FLAG tag. Produced DIVA vaccines may be stable through multiple passes and thus may be effective for production and vaccination of animals.
