A pressure sensor suitable for use in a powered contrast injector system may be tested to help validate the operability and/or integrity of the sensor. In some examples, the pressure sensor may be tested by generating a pressure pulse in a fluid line fluidly connected to the pressure sensor so as to generate a first pressure reading. A high pressure fluid at a pressure above a maximum operating pressure of the pressure sensor may be conveyed through a valve fluidly connected to the pressure sensor. Subsequent to conveying the high pressure fluid through the valve, the pressure sensor may again be tested by generating a pressure pulse in the fluid line fluidly connected to the pressure sensor so as to generate a second pressure reading. In some examples, the first pressure reading is compared to the second pressure reading to determine whether the pressure sensor has passed or failed.
