A SERIES OF QUINOLONE AND QUINOXALINE DERIVATIVES COMPRISING A FLUORINATED ETHYL SIDE-CHAIN, BEING SELECTIVE INHIBITORS OF PI3 KINASE ENZYMES, ARE ACCORDINGLY OF BENEFIT IN MEDICINE, FOR EXAMPLE IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE, CARDIOVASCULAR, NEURODEGENERATIVE, METABOLIC, ONCOLOGICAL, NOCICEPTIVE OR OPHTHALMIC CONDITIONS.