Disclosed is a method of preparing a device comprising a stent and a plurality of layers that form a laminate coating on said stent； said method comprising: (a) providing a stent； (b) discharging at least one pharmaceutical agent and/or at least one active biological agent in dry powder form through a first orifice； (c) forming a supercritical or near supercritical fluid solution comprising at least one supercritical fluid solvent and at least one polymer and discharging said supercritical or near supercritical fluid solution through a second orifice under conditions sufficient to form solid particles of the polymer； (d) depositing the polymer and pharmaceutical agent and/or active biological agent particles onto said substrate, wherein an electrical potential is maintained between the substrate and the polymer and pharmaceutical agent and/or active biological agent particles, thereby forming said coating； and (e) sintering said coating under conditions that do not substantially modify a morphology of said pharmaceutical agent and/or activity of said biological agent.
