Provided herein are methods and devices for treatment of migraines or other headaches. In various aspects, one illustrative method may include steps of applying a contact tip of a device to an external tissue in an area of the skull of a subject, and administering a low temperature stimulation for a period of time. The contact tip of the device may be operably connected with a case and a low temperature stimulation module such that the contact tip provides low temperature stimulation. Various other features may also be included.
