HACKET, FRANK,HEY, THOMAS,HAUSCHILD, FRANZISKA,KNOLLER, HELMUT,SCHIMMEL, MARTIN,SOMMERMEYER, KLAUS
申请号：
NZ58602108
公开号：
NZ586021A
申请日:
2008.12.15
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed herein is a method for the preparation of a hydroxyalkyl starch (HAS) derivative of formula (III), comprising reacting a hydroxyalkyl starch (HAS) of formula (I) via carbon atom C* of the reducing end of the HAS with the amino group M of a crosslinking compound according to formula (II), wherein A represents an acetal or ketal group and L is a spacer bridging M and A, wherein C* is optionally oxidised prior to the reaction of HAS with M to obtain a HAS derivative according to formula (III), wherein the substituents are as defined within the specification. Also disclosed is the hydroxyalkyl starch derivative of formula (III) and (IV). Such compounds are useful in the stabilization of polypeptides.
