BRACE, GARETH NEIL,CHOVATIA, PRAFULKUMAR TULSHIBHAI,FOULKES, GREGORY,JOHNSON, JAMES ANDREW,JONES, SEVERINE DANIELLE,KROEPLIEN, BORIS,LECOMTE, FABIEN CLAUDE,LOKE, PUI LENG,LOWE, MARTIN ALEXANDER,MANDAL
申请号:
CA2986651
公开号:
CA2986651A1
申请日:
2016.06.07
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
A series of substituted 3,4-dihydro-2H-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neuradegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.