Peter I. Lelkes,Mengyan Li,Anat Perets,Pimporn Uttayarat,Robert J. Levy,Russell J. Composto
申请号：
US13511511
公开号：
US20130018454A1
申请日:
2010.11.24
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a hybrid graft and methods of generating the hybrid graft. The hybrid graft comprises an exterior surface and a luminal surface. The luminal surface comprises a micropattern of grooves to which cells adhere and orient along. The exterior surface comprises electrospun microfibers wherein the microfibers provide mechanical properties to the graft. The hybrid graft is capable supporting endothelial cell attachment, endothelial cell alignment, cell proliferation, and maintaining their in vivo function. The graft of the invention can recapitulate the in vivo morphology and function of natural vascular endothelium.
