HYUN, TAEG HWAN,현택환,OH, MYOUNG HWAN,오명환,LEE, NO HYUN,이노현
申请号：
KR1020120036615
公开号：
KR1020130114346A
申请日:
2012.04.09
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A transition metal oxide/tantalum oxide core/shell nanoparticle is provided to be used as an X-ray CT contrast agent and an MRI T2 contrast agent by combining a biocompatible molecule or ligand on the surface of a tantalum oxide shell.CONSTITUTION: A core/shell nanoparticle comprises a transition metal oxide core and a tantalum oxide shell. The transition metal oxide is selected from ferric oxide, manganese oxide, ceria, titanium oxide, nickel oxide, cobalt oxide, and zinc oxide. The size of the transition metal oxide is 1-100 nm, and the thickness of the tantalum oxide shell is 1-50 nm. A silane group or a phosphine group is combined to the surface of the tantalum oxide shell, and a functional material is combined to the silane group or the phosphine group. The functional material is selected from a biocompatible material, organic dye, a bioactive material, a functional group, an organic molecule, organic metal, a nanoparticle, a shell structure, or a combination thereof.COPYRIGHT KIPO 2013본 발명은 전이금속 산화물/산화탄탈륨 코어/쉘 나노입자, 이의 제조 방법 및 이를 포함하는 X-선 CT 조영제 및 MRI 조영제에 관한 것이다. 보다 상세하게는, 본 발명은 전이금속 산화물 코어 및 상기 전이금속 산화물 코어의 둘레에 형성된 산화탄탈륨 쉘을 포함하는 코어/쉘 나노입자, 이의 제조 방법, 및 이를 포함하는 X-선 CT 조영제 및 MRI 조영제에 대한 것이다.
