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COMPOSITIONS FOR THE TREATMENT OF INTESTINAL DISORDERS
专利权人:
NOVINTETHICAL PHARMA SA
发明人:
Miguel Angel ALONSO COHEN,Marco DI FULVIO
申请号:
US16099289
公开号:
US20190209647A1
申请日:
2017.05.08
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The invention provides a process for preparing a protein-polysaccharide conjugated product comprising: (a) preparing a mixture comprising pea protein, polysaccharide, and an appropriate polar solvent; wherein: the weight ratio between polysaccharide and protein is comprised from 20:80 to 60:40, and the pH of the solution is comprised from 8.0 to 10.5; and performing a Maillard reaction by heating the solution resulting from step (a) at an appropriate temperature for the necessary period of time to conjugate the protein and the polysaccharide. The invention further provides a conjugated product obtainable by the process of the invention, as well as pharmaceutical compositions comprising the conjugate and to their use in the treatment in gastrointestinal disorders. The conjugate of the invention shows a remarkable improvement in preventing and/or treating intestinal diseases, such as mucositis.
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