The present invention relates to a bone substitute material for implantation, comprising (a) the bone allograft to be implanted covered with (b) a controlled release coating containing (c) at least one biologically active substance that decreases bacterial growth, wherein the (b) controlled release coating is a bioavailable, biocompatible polymer material and wherein the (c) at least one biologically active substance that decreases bacterial growth can be any antibiotics or a mixture thereof. The present invention also relates to a method to prepare the bone substitute material, as wells the uses thereof.
