SUBSTITUTED 6,7-DIALKOXY-3-ISOQUINOLINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE10A)农业专利-农业学术服务平台

发明人:: LEBLOND, BERTRAND,李宝纳德伯坦德,李寶納德伯坦德,TAVERNE, THIERRY,泰魏恩喜尔瑞,泰魏恩喜爾瑞,CHAUVIGNAV, CEDRIC,乔维格纳维赛德瑞克,喬維格納維賽德瑞克,BEAUSOLEIL, ERIC,毕尤索里尔艾瑞克,畢尤索里爾艾瑞克,CASAGRANDE, ANNE-SOPHIE,凯萨葛蓝安苏菲,凱薩葛藍安蘇菲,DESIRE, L

摘要：: The invention relates to compounds of the formula or a pharmaceutically acceptable salt thereof, wherein R, R1 through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.本發明係關於下式之化合物或其醫藥學上可接受之鹽,其中R、R1至R7及Ar係如本文中所定義。此等化合物適用作磷酸二酯酶10(PDE10A)抑制劑,其適用於治療中樞神經系統疾病,諸如精神病,且亦適用於治療例如肥胖症、II型糖尿病、代謝症候群、葡萄糖失耐症、疼痛及眼科疾病。