The invention provides compounds of formula I or pharmaceutically acceptable salt thereof Wherein B1, B2, B3 and B4 represent independently C(R3)； X represents -CH(R5)-, -C(R5)= or -(C=O)-, and wherein when X represents -CH(R5)- or -(C=O)- the dotted line represents a single bond, and when X represents -C(R5)= the dotted line represents a double bond； R1 represents independently at each occurrence methy, ethyl, methoxy or ethoxy； R2 represents halogen, cyano, hydroxyl, methyl, ethyl, methoxy, ethoxy, -N(R6a)(R6b) or -methylene-N(R6a)(R6b)； R3 represents independently at each occurrence hydrogen, halogen, cyano or methyl； R4a represents methyl or ethyl； R4b represents halogen, C1-C4alkyl, C1-C4alkoxy or -O-C1-C4alkylene-Cycle-Q； R5 represents hydrogen or methyl； R6a represents hydrogen or methyl； R6b represents hydrogen or methyl； Cycle-Q represents independently at each occurrence phenyl optionally substituted by 1 to 3 R7； R7 represents independently at each occurrence cyano, methyl, halomethyl, methoxy or halomethoxy； n is 1 or 2； and q is 0, 1 or 2； as well as methods of using the compounds to treat proliferation diseases, in particular cancer.本發明提供了式I之化合物或其藥學上可接受的鹽其中B1、B2、B3和B4獨立地表示C(R3)；X表示-CH(R5)-、-C(R5)=或-(C=O)-，並且其中當X表示-CH(R5)-或-(C=O)-時，虛線表示單鍵，而當X表示-C(R5)=時，虛線表示雙鍵；R1在每次出現時獨立地表示甲基、乙基、甲氧基或乙氧基；R2表示鹵素、氰基、羥基、甲基、乙基、甲氧基、乙氧基、-N(R6a)(R6b)或-亞甲基-N(R6a)(R6b)；R3在每次出現時獨立地表示氫、鹵素、氰基或甲基；R4a表示甲基或乙基；R4b表示鹵素、C1-C4烷基、C1-C4烷氧基或-O-C1-C4伸烷基-環-Q；R5表示氫或甲基；R6a表示氫或甲基；R6b表示氫或甲基；環-Q在每次出現時獨立地表示視需要被1至3個R7取代的苯基；R7在每次出現時獨立地表示氰基、甲基、鹵代甲基、甲氧基或鹵代甲氧基；n係1或2；並且q係0、1或2；以及使用該等化合物治療增生性疾病，特別是癌症的方法。
