This invention provides a pharmaceutical composition as an effective means for treating infective diseases, especially infective diseases fromPseudomonas aeruginosa, which comprises a humanized monoclonal antibody or a part thereof against PcrV as an active ingredient. Specifically, the humanized monoclonal antibody has an excellent inhibition on cell damage whilePseudomonas aeruginosatargets the cell. In addition, the humanized monoclonal antibody of the present invention has high affinity against PcrV.提供一種含有抗PcrV之人化單株抗體或其一部分及此等為有效成分之醫藥組成物,作為感染症,特別是因綠膿桿菌之感染症的治療有效的手段。具體言之,本發明之人化單株抗體,對綠膿桿菌之標靶細胞的細胞傷害性之阻害活性優異。此外,本發明之人化單株抗體抗PcrV有高親和性。
