The present invention relates to a composition for alcohol or acetaldehyde degradation, which comprises probiotics. The composition of the present invention has a significant synergistic effect on the degradation of alcohol or acetaldehyde, when the probiotics are administered alone or in combination or the composition further comprises excipients. In addition, the composition according to the present invention may effectively degrade alcohol and acetaldehyde, thereby not only treating or preventing alcohol-induced diseases, but also effectively relieving hangovers caused by excessive drinking.