PORCINE KNOB XENOTYPE CHIMERIC ADENOVIRAL VECTOR FOR DENDRITIC CELL INFECTION

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专利权人:

WASHINGTON UNIVERSITY

发明人:

CURIEL, DAVID

申请号：

EP12858372

公开号：

EP2798069A4

申请日:

2012.12.14

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Disclosed are methods of transforming dendritic cells with a chimeric adenovirus-5 (Ad5). A chimeric adenovirus includes a fiber comprising a tail, a shaft and a knob, wherein the knob is a porcine knob, and a nucleic acid comprising a promoter operably linked to a heterologous sequence encoding an antigen peptide.

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