A method of treating a disease state or condition in mammalsans via topical brainstem afferent stimulation therapy via the administration of a cannabinoid drug(s) to the back of the neck of a human patient to provide regional neuro affective therapy is disclosed. In certain preferred embodiments the cannabinoid drug(s) are not psychoactive or substantially not psychoactive. In certain embodiments the cannabinoid drug(s) are incorporated into a pharmaceutically acceptable topical carrier e.g. a cream. In certain preferred embodiments the cannabinoid drug(s) comprises cannabidiol.
