The present invention relates to methods for the treatment of gastrointestinal cancers. In particular, the invention provides methods for treatment of a gastrointestinal cancer by administering an immunoconjugate comprising an anti-GCC antibody molecule in combination with a DNA damaging agent.本發明係關於用於治療胃腸癌之方法。特定而言,本發明提供用於藉由投予包含抗-GCC抗體分子之免疫共軛物與DNA破壞劑之組合來治療胃腸癌之方法。