A method for reversed modeling of biomedical model of the present invention comprises at least the following steps: (a) Obtaining the data of a first model； (b) Transferring data of the first model into data of a second model which are applied to a rapid Prototyping machine； (c) Entering data of the second model into the rapid prototyping machine； (d) Laying model materials, coating adhesives and continuing sterilization by the rapid prototyping machine and stacking until a biomedical model is made； wherein sterilization is done during stacking medical model, therefore keeping the biomedical model sterile inside is achieved.
