A system and methodology for treatment of circulation related conditions in hooved animals such as laminitis in horses. The methodology employs a garment wrap(20) that is releasably secured to the animal's leg. The wrap includes several inflatable chambers(40, 42, 44, 46, 48), one of which, the most distal one(40,l 12), engages at least the frog(82) and/or bulbar(84) sections of the horse's hoof. The methodology calls for the pressuring of the inflatable chambers in accordance with a sequence that prevents backflow from a more proximal point on the animal's leg to a more distal point on the leg. A boot arrangement(24) including an inner sole pad(l 14) are also utilized both during the therapy procedure and afterwards. The inner sole pad can provide related medications and can be used in an iontophoresis procedure.