KARRI V V S NARAYANA REDDY,KARRI V V S NARAYANA REDDY,RAJKUMAR MALAYANDI,RAJKUMAR MALAYANDI,R SURESH KUMAR,R SURESH KUMAR,GOWTHAMARAJAN KUPPUSAMY,GOWTHAMARAJAN KUPPUSAMY
申请号：
IN1186/CHE/2013
公开号：
IN2013CH01186A
申请日:
2013.03.20
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
Terbinafine HC1 is insoluble in aqueous solutions and has poor permeability after the topical administration. Nano emulsions in size range less than 2 nm and less than 20 nm containing Terbinafine HC1 have been successfully prepared using high pressure and high speed homogenization techniques and then incorporated in to Carbopol gels in order to improve its permeability. In vitro comparative release studies of formulated gels and marketed cream were performed using pork dorsal ear skin. The permeability of nano emulsion gels was significantly increased compared with that of the marketed fungicide cream. In vivo anti fungal studies were performed on male albino Wistar rats for 14 days. Our studies confirmed that the use of nano emulsion gels containing globule size less than2 nm or less than 20 nm can improve the permeability performance and the efficacy of Terbinafine HC1 to treat topical fungal infections.
