Disclosed are compositions of matter treatment protocols and combination therapies aimed at stimulating neoangiogensis in ischemia tissue and means of acceleration host ischemic healing. In one embodiment antibiotics are administered to a patient in need of therapy, said antibiotics of endogenious microflora. Subsequently probiotic and or probiotic and prebiotic are administered to generate “natural” microflora. Said reconstituted microflora provides a means for generation of cardiac self-reactive T regulatory cells capable of stimulating angiogenesis and or myocardial protection.
