The technology described herein relates to weight and activity monitoring footwear. In an implementation, an article of footwear is disclosed. The article of footwear includes a sole, a plurality of pressure sensors, a motion sensor, and a microcontroller. The sole has a plurality of pressure chambers. The plurality of pressure sensors take pressure readings from the plurality of pressure chambers. The motion sensor senses motion of the article of footwear. The microcontroller is operatively coupled with the plurality of pressure sensors and the motion sensor and is configured to detect when a subject enters a standing state from the motion of the article of footwear, and in response to detecting the standing state, determine a weight applied by the subject against the sole from the pressure readings. The plurality of pressure chambers are disposed to support the weight applied by the subject against the sole in the standing state.