KARP, JEFFREY,JOSHI, NITIN,HE, XUEYIN,AMIRAULT, JULIAN,LARAMEE, BRITTANY,SLAUGHTER, KAI
申请号：
CA3062885
公开号：
CA3062885A1
申请日:
2017.05.08
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Gels are formed based on generally recognized as safe (GRAS) low molecular weight amphiphilic molecules in a self-assembly process with limited or no heating. A selective range of ratios between an organic solvent and water, or an aqueous solution, in the medium, allows for the GRAS low molecular weight amphiphiles to form a homogeneous self-supporting gel encapsulating agents to be delivered under very mild conditions. Proteins including enzymes, antibodies, and serum albumin are loaded in the self- assembled gels to provide sustained and/or responsive delivery. The encapsulated proteins retain at least 70%, 80%, or 90% of their activity over days in various storage conditions.
