Jeffrey A. Ledbetter;Martha Susan Hayden-Ledbetter
发明人:
Jeffrey A. Ledbetter,Martha Susan Hayden-Ledbetter
申请号：
US12901297
公开号：
US08197810B2
申请日:
2010.10.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to novel binding domain-immunoglobulin fusion proteins that feature a binding domain for a cognate structure such as an antigen, a counterreceptor or the like, a hinge region polypeptide having either zero or one cysteine residue, and immunoglobulin CH2 and CH3 domains, and that are capable of ADCC and/or CDC while occurring predominantly as monomeric polypeptides. The fusion proteins can be recombinantly produced at high expression levels. Also provided are related compositions and methods, including immunotherapeutic applications.
