Described are biomarkers and associated methods for determining aprognosis for a subject with leukemia and/or for detecting LeukemicRegenerating Cells (LRCs) or Hematopoietic Regenerating Cells. Whilechemotherapy may successfully deplete leukemic stem cells (LSCs), amolecularly distinct population of LRCs are observed following cytotoxicchemotherapy not seen in therapy naïve subjects with leukemia or healthyhematopoietic cell populations. Also described are methods for the treatmentof leukemia that target LRCs in a subject in need thereof.
