601408 Disclosed are 5-aryl-isothiazol-3-ol 1-oxide derivatives / 1-oxo-5-aryl-isothiazolidin-3-one derivatives as represented by the general formula (I), where n is an integer of 1； p is an integer of 0 to 4； j is an integer 5 of 0 to 3； k is an integer of 0 to 2； ring A is a C6-14 aryl group which is optionally substituted with 1 to 5 L(s) or a 3- to 14-membered heterocyclic group which is optionally substituted with 1 to 5 L(s)； ring B is a benzene ring, a pyridine ring, or a pyrimidine ring； X is an oxygen atom, a sulfur atom, or -NR7-； and wherein the remaining substituents are as defined herein. Representative compounds include 5-(4-((3-(2,6-dimethyl-4-(2-ethoxyethoxy)phenyl)phenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide； 5-(4-((3-(2,4-dimethyl-6-(3-hydroxy-3-methylbutoxy)pyridin-3-yl)phenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide； 5-(4-((3-(2,6-dimethyl-3-fluoro-4-(3-(2-oxopyrrolidin-1-yl)propoxy)phenyl)phenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide； 5-(4-((3-(2,6-dimethyl-3-fluoro-4-((3-methyl-3-oxetanyl)methoxy)phenyl)phenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide； 5-(4-((3-(2,6-dimethyl-4-(3-(methylsulfonyl)propoxy)phenyl)phenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide； 5-(4-((3-(2,6-dimethyl-4-(3-hydroxypropoxy)phenyl)phenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide； 5-(4-((3-(2,4-dimethyl-6-(3-hydroxypropoxy)pyridin-3-yl)phenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide； 5-(4-((3-(4-((2R)-2,3-dihydroxypropoxy)-2,6-dimethyl-3-fluorophenyl)phenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide； 5-(4-((3-(2,6-dimethyl-4-((3R)-3-hydroxybutoxy)phenyl)phenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide； N-[3-[4-[3-[[4-(3-hydroxy-1-oxo-isothiazol-5-yl)phenoxy]methyl]phenyl]-3,5-dimethylphenoxy]propyl]methanesulfonamide； 5-[4-[[3-[4-(3-aminopropoxy)-2,6-dimethylphenyl]phenyl]methoxy]phenyl]isothiazol-3-ol 1-oxide； 5-[4-[[(1R)-4-(6-methoxy-2-methylpyridin-3-yl)-2,3-dihydro-1H-inden-1-yl]oxy]phenyl]isothiazol-3-ol 1-oxide trifluoroacetate salt； 5-[4-[[(1R)-4-[6-(3-hydroxy-3-methylbutoxy)-2-m
