ALEXANDER HAAS,EIKE HOFFMANN,GUY GEORGES,JOERG BENZ,MICHAEL GROTE,SEBASTIAN DZIADEK,STEFAN DENGL,ULRICH BRINKMANN
申请号:
BR112014029403
公开号:
BR112014029403A2
申请日:
2013.07.04
申请国别(地区):
BR
年份:
2018
代理人:
摘要:
Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.