Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin

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专利权人:

Donald M. Miller

发明人:

Donald M. Miller,Paula J. Bates,John O. Trent

申请号：

US10978032

公开号：

US08648051B2

申请日:

2004.10.29

申请国别(地区):

US

年份:

2014

代理人:

摘要：

The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.

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