Thuy-Anh Tran,Rena Hayashi,Jason B. Ibarra,Brett Ullman,Ning Zou
申请号：
US15230825
公开号：
US10138210B2
申请日:
2016.08.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders； platelet aggregation； coronary artery disease； myocardial infarction； transient ischemic attack； angina； stroke； ischemia-reperfusion injury； restenosis； atrial fibrillation； blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation； atherosclerosis； atherothrombosis； asthma or a symptom thereof； a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy； glaucoma or other disease of the eye with abnormal intraocular pressure； hypertension； inflammation； psoriasis； psoriatic arthritis； rheumatoid arthritis； Crohn's disease； transplant rejection； multiple sclerosis； systemic lupus erythematosus (SLE)； ulcerative colitis； ischemia-reperfusion injury； restenosis； atherosclerosis； acne； type 1 diabetes； type 2 diabetes； sepsis； and chronic obstructive pulmonary disorder (COPD).
